Quarterly report pursuant to Section 13 or 15(d)

Condensed Consolidated Statements of Changes in Stockholders' Equity

v3.19.3
Condensed Consolidated Statements of Changes in Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Underwritten Public Offering
At The Market Offering
Common Stock
Common Stock
Underwritten Public Offering
Common Stock
At The Market Offering
Additional Paid-in Capital
Additional Paid-in Capital
Underwritten Public Offering
Additional Paid-in Capital
At The Market Offering
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance at Dec. 31, 2017 $ 177,864     $ 3     $ 474,662     $ (151) $ (296,650)
Beginning balance (in shares) at Dec. 31, 2017       30,730              
Issuance of common stock, net Of offering costs, values   $ 293,289     $ 1     $ 293,288      
Issuance of common stock, net Of offering costs, shares         12,604            
RSU settlements, net of shares withheld (3,363)           (3,363)        
RSU settlements, net of shares withheld, shares       250              
Issuance of common stock pursuant to employee stock awards 6,196           6,196        
Issuance of common stock pursuant to employee stock awards, shares       309              
Stock-based compensation expense 7,014           7,014        
Net loss (41,443)                   (41,443)
Unrealized gain [loss] on available-for-sale securities (373)                 (373)  
Ending balance at Mar. 31, 2018 439,184     $ 4     777,797     (524) (338,093)
Ending balance (in shares) at Mar. 31, 2018       43,893              
Beginning balance at Dec. 31, 2017 177,864     $ 3     474,662     (151) (296,650)
Beginning balance (in shares) at Dec. 31, 2017       30,730              
Net loss (150,687)                    
Unrealized gain [loss] on available-for-sale securities (298)                    
Ending balance at Sep. 30, 2018 403,054     $ 5     850,835     (449) (447,337)
Ending balance (in shares) at Sep. 30, 2018       45,645              
Beginning balance at Mar. 31, 2018 439,184     $ 4     777,797     (524) (338,093)
Beginning balance (in shares) at Mar. 31, 2018       43,893              
Issuance of common stock, net of commissions and offering costs, value     $ 47,587     $ 1     $ 47,586    
Issuance of common stock, net of commissions and offering costs, shares           1,008          
RSU settlements, net of shares withheld (67)           (67)        
RSU settlements, net of shares withheld, shares       42              
Issuance of common stock pursuant to employee stock awards 8,661           8,661        
Issuance of common stock pursuant to employee stock awards, shares       391              
Stock-based compensation expense 7,998           7,998        
Net loss (50,883)                   (50,883)
Unrealized gain [loss] on available-for-sale securities 19                 19  
Ending balance at Jun. 30, 2018 452,499     $ 5     841,975     (505) (388,976)
Ending balance (in shares) at Jun. 30, 2018       45,334              
RSU settlements, net of shares withheld (4,063)           (4,063)        
RSU settlements, net of shares withheld, shares       153              
Issuance of common stock pursuant to employee stock awards 3,671           3,671        
Issuance of common stock pursuant to employee stock awards, shares       158              
Stock-based compensation expense 9,252           9,252        
Net loss (58,361)                   (58,361)
Unrealized gain [loss] on available-for-sale securities 56                 56  
Ending balance at Sep. 30, 2018 403,054     $ 5     850,835     (449) (447,337)
Ending balance (in shares) at Sep. 30, 2018       45,645              
Effect of the adoption of ASC topic 842 (Leases) at Jan. 1, 2019 364                   364
Balance at Jan. 1, 2019 339,221     $ 5     866,541     (340) (526,985)
Beginning balance at Dec. 31, 2018 338,857     $ 5     866,541     (340) (527,349)
Beginning balance (in shares) at Dec. 31, 2018       45,951              
RSU settlements, net of shares withheld (4,575)           (4,575)        
RSU settlements, net of shares withheld, shares       197              
Issuance of common stock pursuant to employee stock awards 2,898           2,898        
Issuance of common stock pursuant to employee stock awards, shares       159              
Stock-based compensation expense 12,269           12,269        
Net loss (66,257)                   (66,257)
Unrealized gain [loss] on available-for-sale securities 378                 378  
Ending balance at Mar. 31, 2019 283,934     $ 5     877,133     38 (593,242)
Ending balance (in shares) at Mar. 31, 2019       46,307              
Beginning balance at Dec. 31, 2018 338,857     $ 5     866,541     (340) (527,349)
Beginning balance (in shares) at Dec. 31, 2018       45,951              
Net loss (212,480)                    
Unrealized gain [loss] on available-for-sale securities 573                    
Ending balance at Sep. 30, 2019 318,442     $ 5     1,057,669     233 (739,465)
Ending balance (in shares) at Sep. 30, 2019       54,125              
Beginning balance at Mar. 31, 2019 283,934     $ 5     877,133     38 (593,242)
Beginning balance (in shares) at Mar. 31, 2019       46,307              
Issuance of common stock, net of commissions and offering costs, value     7,630           7,630    
Issuance of common stock, net of commissions and offering costs, shares           359          
RSU settlements, net of shares withheld (2,095)           (2,095)        
RSU settlements, net of shares withheld, shares       120              
Issuance of common stock pursuant to employee stock awards 1,802           1,802        
Issuance of common stock pursuant to employee stock awards, shares       97              
Stock-based compensation expense 15,201           15,201        
Net loss (74,328)                   (74,328)
Unrealized gain [loss] on available-for-sale securities 135                 135  
Ending balance at Jun. 30, 2019 232,279     $ 5     899,671     173 (667,570)
Ending balance (in shares) at Jun. 30, 2019       46,883              
Issuance of common stock and pre-funded warrants, net of offering costs, value   $ 140,711           $ 140,711      
Issuance of common stock and pre-funded warrants, net of offering costs, shares         6,872            
Issuance of common stock, net of commissions and offering costs, value     $ 5,000           $ 5,000    
Issuance of common stock, net of commissions and offering costs, shares           327          
RSU settlements, net of shares withheld (25)           (25)        
RSU settlements, net of shares withheld, shares       32              
Issuance of common stock pursuant to employee stock awards 160           160        
Issuance of common stock pursuant to employee stock awards, shares       11              
Stock-based compensation expense 12,152           12,152        
Net loss (71,895)                   (71,895)
Unrealized gain [loss] on available-for-sale securities 60                 60  
Ending balance at Sep. 30, 2019 $ 318,442     $ 5     $ 1,057,669     $ 233 $ (739,465)
Ending balance (in shares) at Sep. 30, 2019       54,125