v3.19.3.a.u2
Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Operating expenses:      
Research and development $ 216,097 $ 167,457 $ 81,206
General and administrative 79,584 69,654 40,326
Total operating expenses 295,681 237,111 121,532
Loss from operations (295,681) (237,111) (121,532)
Interest and other income, net 4,717 6,368 2,027
Loss before provision for income taxes (290,964) (230,743) (119,505)
Provision for (benefit from) income taxes 12 (44) (14)
Net loss (290,976) (230,699) (119,491)
Other comprehensive gain (loss):      
Unrealized gain (loss) on available-for-sale securities 560 (189) 32
Comprehensive loss $ (290,416) $ (230,888) $ (119,459)
Net loss per common share:      
Basic and diluted net loss per common share $ (5.67) $ (5.27) $ (4.00)
Weighted-average shares outstanding used to calculate basic and diluted net loss per common share 51,308 43,811 29,863

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