v3.20.4
Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Operating expenses:      
Research and development $ 244,650 $ 216,097 $ 167,457
General and administrative 64,402 79,584 69,654
Total operating expenses 309,052 295,681 237,111
Loss from operations (309,052) (295,681) (237,111)
Interest and other income, net 2,447 4,717 6,368
Loss before provision for income taxes (306,605) (290,964) (230,743)
Provision for (benefit from) income taxes 15 12 (44)
Net loss (306,620) (290,976) (230,699)
Other comprehensive gain (loss):      
Unrealized gain (loss) on available-for-sale securities 76 560 (189)
Comprehensive loss $ (306,544) $ (290,416) $ (230,888)
Net loss per common share:      
Basic and diluted net loss per common share $ (4.15) $ (5.67) $ (5.27)
Weighted-average shares outstanding used to calculate basic and diluted net loss per common share 73,973 51,308 43,811

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