Quarterly report pursuant to Section 13 or 15(d)

License, Collaboration and Manufacturing Agreements - Additional Information (Detail)

v3.10.0.1
License, Collaboration and Manufacturing Agreements - Additional Information (Detail) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Sep. 30, 2016
Dec. 31, 2015
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Related Party Transaction [Line Items]              
Cash paid to exercise option agreement         $ 4,500,000    
Potential milestone payments payable $ 33,000,000       33,000,000    
Research and development expense 33,387,000 $ 18,296,000     61,847,000 $ 35,837,000  
Contractual obligations due MSK and QIMR 0       0   $ 0
QIMR Berghofer              
Related Party Transaction [Line Items]              
Research and development expense $ 1,300,000 $ 700,000     $ 2,400,000 $ 1,300,000  
License Agreement | QIMR Berghofer              
Related Party Transaction [Line Items]              
Research and development expense     $ 3,300,000        
Payments under license agreement       $ 3,000,000      
Manufacturing Agreements | Cognate Agreement              
Related Party Transaction [Line Items]              
Written notice period for termination of agreement         6 months    
Manufacturing Agreements | Cognate Agreement | Minimum              
Related Party Transaction [Line Items]              
Standard mutual termination rights period         90 days