Quarterly report pursuant to Section 13 or 15(d)

Stockholders' Equity - Summary of Stock Option Activity (Detail)

v3.22.1
Stockholders' Equity - Summary of Stock Option Activity (Detail) - 2014 EIP and Inducement Plan - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2022
Dec. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]    
Outstanding, Shares, beginning balance 9,219,837  
Granted, Shares 2,352,082  
Exercised, Shares (10,000)  
Forfeited or expired, Shares (405,756)  
Outstanding, Shares, ending balance 11,156,163 9,219,837
Outstanding, Weighted Average Exercise Price, beginning balance $ 20.81  
Granted, Weighted Average Exercise Price 10.46  
Exercised, Weighted Average Exercise Price 9.58  
Forfeited or expired, Weighted Average Exercise price 24.99  
Outstanding, Weighted Average Exercise Price, ending balance $ 18.49 $ 20.81
Outstanding, Weighted Average Remaining Contractual Term 6 years 9 months 18 days 6 years 4 months 24 days
Aggregate intrinsic value $ 328 $ 12,810