Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Stockholders' Equity

v3.20.4
Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Cumulative Effect, Period of Adoption, Adjustment
Cumulative Effect, Period of Adoption, Adjusted Balance
At The Market Offering
Underwritten Public Offering
Common Stock
Common Stock
Cumulative Effect, Period of Adoption, Adjusted Balance
Common Stock
At The Market Offering
Common Stock
Underwritten Public Offering
Additional Paid-in Capital
Additional Paid-in Capital
Cumulative Effect, Period of Adoption, Adjusted Balance
Additional Paid-in Capital
At The Market Offering
Additional Paid-in Capital
Underwritten Public Offering
Accumulated Other Comprehensive Income (Loss)
Accumulated Other Comprehensive Income (Loss)
Cumulative Effect, Period of Adoption, Adjusted Balance
Accumulated Deficit
Accumulated Deficit
Cumulative Effect, Period of Adoption, Adjustment
Accumulated Deficit
Cumulative Effect, Period of Adoption, Adjusted Balance
Beginning balance at Dec. 31, 2017 $ 177,864         $ 3       $ 474,662       $ (151)   $ (296,650)    
Beginning balance (in shares) at Dec. 31, 2017           30,730                        
Issuance of common stock, net of offering costs, values         $ 293,290       $ 2       $ 293,288          
Issuance of common stock, net Of offering costs, shares                 12,604                  
Issuance of common stock, net of commissions and offering costs, value       $ 47,586               $ 47,586            
Issuance of common stock, net of commissions and offering costs, shares               1,008                    
RSU settlements, net of shares withheld (7,503)                 (7,503)                
RSU settlements, net of shares withheld, shares           449                        
Issuance of common stock pursuant to employee stock awards 24,691                 24,691                
Issuance of common stock pursuant to employee stock awards, shares           1,160                        
Stock-based compensation expense 33,817                 33,817                
Net loss (230,699)                             (230,699)    
Unrealized gain (loss) on available-for-sale securities (189)                         (189)        
Ending balance at Dec. 31, 2018 $ 338,857 $ 364 $ 339,221     $ 5 $ 5     866,541 $ 866,541     (340) $ (340) (527,349) $ 364 $ (526,985)
Ending balance (in shares) at Dec. 31, 2018           45,951 45,951                      
Accounting Standards Update Extensible List us-gaap:AccountingStandardsUpdate201602Member                                  
Issuance of common stock and pre-funded warrants, net of offering costs         140,716       $ 1       140,715          
Issuance of common stock and pre-funded warrants, net of offering costs, shares                 6,872                  
Issuance of common stock, net of commissions and offering costs, value       48,909               48,909            
Issuance of common stock, net of commissions and offering costs, shares               3,135                    
RSU settlements, net of shares withheld $ (6,695)                 (6,695)                
RSU settlements, net of shares withheld, shares           361                        
Issuance of common stock pursuant to employee stock awards 7,350                 7,350                
Issuance of common stock pursuant to employee stock awards, shares           487                        
Stock-based compensation expense 51,696                 51,696                
Net loss (290,976)                             (290,976)    
Unrealized gain (loss) on available-for-sale securities 560                         560        
Ending balance at Dec. 31, 2019 290,781         $ 6       1,108,516       220   (817,961)    
Ending balance (in shares) at Dec. 31, 2019           56,806                        
Issuance of common stock and pre-funded warrants, net of offering costs         $ 353,588       $ 2       $ 353,586          
Issuance of common stock and pre-funded warrants, net of offering costs, shares                 20,060                  
Issuance of common stock, net of commissions and offering costs, value       $ 68,004               $ 68,004            
Issuance of common stock, net of commissions and offering costs, shares               4,786                    
Exercise of pre-funded warrants, shares           57                        
RSU settlements, net of shares withheld (1,521)                 (1,521)                
RSU settlements, net of shares withheld, shares           1,112                        
Issuance of common stock pursuant to employee stock awards 6,680                 6,680                
Issuance of common stock pursuant to employee stock awards, shares           551                        
Stock-based compensation expense 51,351                 51,351                
Net loss (306,620)                             (306,620)    
Unrealized gain (loss) on available-for-sale securities 76                         76        
Ending balance at Dec. 31, 2020 $ 462,339         $ 8       $ 1,586,616       $ 296   $ (1,124,581)    
Ending balance (in shares) at Dec. 31, 2020           83,372